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Ro-3306
CAS No. 872573-93-8
Ro-3306 ( Ro3306 )
Catalog No. M16345 CAS No. 872573-93-8
Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 61 | In Stock |
|
| 10MG | 84 | In Stock |
|
| 25MG | 142 | In Stock |
|
| 50MG | 205 | In Stock |
|
| 100MG | 335 | In Stock |
|
| 500MG | 782 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRo-3306
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NoteResearch use only, not for human use.
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Brief DescriptionRo-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
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DescriptionRo-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D; also inhibits CDK1/cyclin A complexes with Ki of 110 nM, shows >15-fold selectivity against a diverse panel of 8 human kinases; reversibly arrests human cells at the G(2)/M border of the cell cycle and allows for effective cell synchronization in early mitosis; enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
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SynonymsRo3306
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1;ERK;PKA;PKCδ;SGK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number872573-93-8
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Formula Weight351.45
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Molecular FormulaC18H13N3OS2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 47 mg/mL
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SMILESO=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3
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Chemical Name4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vassilev LT, et al. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.
2. Kojima K, et al. Cancer Sci. 2009 Jun;100(6):1128-36.
3. Krasinska L, et al. Cell Cycle. 2008 Jun 15;7(12):1702-8.
4. Vassilev LT. Cell Cycle. 2006 Nov;5(22):2555-6.
2. Kojima K, et al. Cancer Sci. 2009 Jun;100(6):1128-36.
3. Krasinska L, et al. Cell Cycle. 2008 Jun 15;7(12):1702-8.
4. Vassilev LT. Cell Cycle. 2006 Nov;5(22):2555-6.
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